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Tramal SR 100mg Tablet 10 'S

Prescription Required

FORMULATramadol HCL 100 mg
COMPANYSearle Pharma


Tramal SR 100mg Tablet 10 'S is a synthetic opioid analog that produces pain suppression at the Central Nervous System (CNS) level. Tramal SR 100mg Tablet 10 'S is clinically prescribed to reduce moderate to severe pain in adults. It modifies the pain perception and response in the brain by acting as an agonist to the opioid receptors involved in analgesia. 

Tramal SR 100mg Tablet 10 'S is also known to act as a serotonin reuptake inhibitor (SNRI) which makes it a potential agent to cause withdrawal symptoms in those who stop using it abruptly. This means that it also has anxiolytic and antidepressant effects to some extent so that Tramal SR 100mg Tablet 10 'S is an effective drug to be given to individuals who are suffering from depression and anxiety associated with pain. 

Long-term use of Tramal SR 100mg Tablet 10 'S is associated with addiction that can lead to overdose and toxicity, especially when it is used along with other opioid analgesics and antidepressants. There is also a risk of serious breathing problems along with sleep apnea. That’s why the usual practice is to initiate the therapy with the least possible dose for the shortest possible time. 

Tramal SR 100mg Tablet 10 'S also acts on certain pain modulators and inflammatory markers. This suggests that Tramal SR 100mg Tablet 10 'S has a broad spectrum of acting as a potent pain-killer which is why it is an effective supportive therapy in the management of neuropathic pain, osteoarthritic pain, fibromyalgia (muscular pain that involves whole-body), back pain, labor & post-operative pain, and pain associated with tumors. 


Tramal SR 100mg Tablet 10 'S is indicated for managing moderate to severe pain in adults which could be chronic to severe. The extended-release formulation of Tramal SR 100mg Tablet 10 'S is used for long-term pain management. However, an immediate-release form is given for short-term pain management. 

How Does Tramal SR 100mg Tablet 10 'S Work

Tramal SR 100mg Tablet 10 'S produces inhibitory effects on the ascending pain pathways by binding to the opioid mu receptors partially (agonistic effect) at the CNS level. Tramal SR 100mg Tablet 10 'S also weakly inhibits serotonin and norepinephrine reuptake. These neurotransmitters are involved in descending pain perception and Tramal SR 100mg Tablet 10 'S makes them available to produce descending pain modulation. This way, Tramal SR 100mg Tablet 10 'S works in synergism with the central nervous system for the modulation of pain perception and response. 

Tramal SR 100mg Tablet 10 'S also produces analgesic effects by affecting other pain modulators in the CNS and markers of the inflammation involved in immune responses such as Prostaglandins E2, Cytokines, and Glial cells. This action aids in multiple clinical manifestations which require pain management as a supportive treatment such as osteoarthritis, labor, and postoperative pain. 

How To Use Tramal SR 100mg Tablet 10 'S

Tramal SR 100mg Tablet 10 'S is a solution for injection that can be administered through IM (Intramuscularly) route or by slow IV (slow intravenous injection). It can also be diluted in solution to get administered for the patient-controlled analgesic effect. Intravenous injection of Tramal SR 100mg Tablet 10 'S should be administered slowly over 2 to 3 minutes. 


Form and strength:

  • 50mg capsule 

  • 100mg tablet

  • 100mg injection (100mg/2ml)

Adult Dose

It is recommended to select the lowest effective dose which may initiate analgesia. The dose should not be exceeded more than 400mg in a day. 

  • The usual dose is 50 or 100mg given at 6 hours of intervals (4 times a day), IM, IV, IV infusion. 

  • The initial dose for postoperative pain is 100mg, administered IV. A further 50mg is given after every 10 to 20 minutes within one hour of administration of the initial dose.  This dosing procedure is continued until the total dose of 250mg is delivered to the patient’s bloodstream. Then the usual dosing schedule of 50 or 100mg is started 6 hourly until the desired response is achieved. 

Pediatric Dose

Tramal SR 100mg Tablet 10 'S should not be given to children below 12 years of age. 

Pregnancy And Lactation 

Tramal SR 100mg Tablet 10 'S is contraindicated to be used in pregnancy as it may cause withdrawal symptoms in the neonate. It may also cause respiratory depression in infants if administered to the mother during labor. Tramal SR 100mg Tablet 10 'S should not be taken by breastfeeding mothers as well as its active metabolite releases in breast milk and may harm the neonate. 


The use of Tramal SR 100mg Tablet 10 'S is contraindicated in the following scenarios:

  • If you are sensitive to opioids, the active ingredients, the excipients used in the formulation of Tramal SR 100mg Tablet 10 'S. 

  • If you have known or suspected obstruction in the GI tract which may or may not be associated with gastrointestinal bleeding. 

  • If you are taking Monoamine oxidase inhibitors (MAOIs) such as Isocarboxazid and Phenelzine, or have taken them in the last 14 days. 

  • Children under 12 years of age or children under 18 years of age who have undergone surgery for the removal of tonsils or adenoids.  

  • Severe or acute bronchial asthma, breathing problems, or respiratory depression.

  • If you are taking sedatives such as sleeping pills, tranquilizers, or alcohol. 


Tramal SR 100mg Tablet 10 'S should be taken with caution under the following circumstances:

  • Taking higher doses than recommended increases the risk of seizures, especially in people who are on opioids or antidepressants. 

  • Tramal SR 100mg Tablet 10 'S should be avoided in individuals who have suicidal tendencies or are prone to addiction. 

  • Tramal SR 100mg Tablet 10 'S is known to develop an addiction. Its misuse may be fatal due to urge, leading to overdose and ultimately death due to respiratory depression. 

  • Newborns may suffer from life-threatening withdrawal symptoms if Tramal SR 100mg Tablet 10 'S is administered during pregnancy. 

  • Intake of alcohol during the treatment with Tramal SR 100mg Tablet 10 'S enhances slow breathing rate and hence causes fatal side effects. So consumption of alcohol or other sedatives should be strictly avoided. 

  • If you feel extreme fatigue, loss of appetite, abdominal pain accompanied by nausea and vomiting, and low blood pressure; you should talk to your doctor as this may suspect adrenal insufficiency. 

  • Tramal SR 100mg Tablet 10 'S can cause sleep-related breathing problems such as sleep apnea in which there is a breathing pause during sleep. It may also cause sleep hypoxemia in which the oxygen levels in the blood go low. If you feel symptoms like shortness of breath, waking up from a deep sleep due to a breathing problem, or disturbed sleeping patterns, you should immediately tell your doctor who might proceed with dose reduction or pause the treatment. 

Interactions With Other Medications

Tramal SR 100mg Tablet 10 'S is known to interaction with some medications. Concomitant administration of them should be avoided:

  • Alvimopan 

  • Procarbazine

  • Rasagiline

  • Safinamide

  • Selegiline

Except for Alvimopan (compete for the receptor site), all other agents increase serotonin levels in the CNS and hence may put the patient at risk of Serotonin Syndrome. 

Other agents that should be avoided during the treatment with Tramal SR 100mg Tablet 10 'S are:

  • Duloxetine

  • Venlafaxine

  • Monoamine oxidase inhibitors (Phenelzine, Isocarboxazid)

  • Opioids (Buprenorphine, Nalbuphine)

  • Ondansetron

  • Narcotics (Codeine, Morphine)

  • Benzodiazepines (Alprazolam, diazepam)

  • Antiplatelets (Warferin) 

  • Tricyclic Antidepressants (Amitriptyline 

  • Ketoconazole

  • Theophylline

Adverse Effects

Common Adverse Effects

  • Drowsiness

  • Nausea

  • Headache

  • Constipation

  • Dry mouth 

  • Sweating 

Potential Adverse Effects 

Tramal SR 100mg Tablet 10 'S has the potential to cause:

  • Rapid breathing (to cope with shortness of breath)

  • Increased heart rate

  • Low blood pressure in the upright position

  • G.I irritation 

  • Serotonin syndrome

  • Respiratory depression in children 

  • Sleep apnea 

  • Sleep-related hypoxemia 

  • Withdrawal symptoms (anxiety, agitation, restlessness, tremor, and GI irritation)

  • Seizures

Rare Adverse Effects

  • Slow heart rhythms 

  • Tingling sensations on the skin

  • Muscle weakness

  • Dilation of Pupils and blurred vision 

  • Allergic reactions such as angioedema and urticaria

  • Nightmares and sleep disturbances

How To Cope With Some Of The Adverse Effects

  • Constipation - Drink a good amount of water and consume a diet rich in fiber such as green leafy vegetables, bananas, and oranges. Exercise daily and start using mild laxatives at bedtime, which act as stool softeners.

  • Drowsiness -  Avoid the usage of caffeine, alcohol, and drugs that make you feel drowsy. Lifting heavy machinery and driving should also be avoided until you get back to normal. 

  • Sleep apnea - Do not sleep in a supine position (on your back). Instead, sleeping on one side f your body can help you breathe normally during sleep. Use a humidifier in your room to retain moisture in the air and have surroundings to breathe easily. This should be followed by smoking or tobacco cessation. 

  • Dry Mouth - Drink lots of water to stay hydrated, avoid medications that may cause dry mouth, use a mouthwash that is free of alcohol, and take sugarless candies and gum to increase salivation. 


  • WHAT IS THE ONSET OF Tramal SR 100mg Tablet 10 'S ACTION?

Tramal SR 100mg Tablet 10 'S starts producing an analgesic effect within one hour of swallowing. 

  • FOR HOW LONG DOES Tramal SR 100mg Tablet 10 'S REMAIN EFFECTIVE?

The duration of action of Tramal SR 100mg Tablet 10 'S is 9 hours.


You should not consume alcohol during or after a certain period of treatment as it may make you feel drowsy and enhance the chances of developing side effects such as breathing difficulty. 

  • DOES Tramal SR 100mg Tablet 10 'S CAUSE WITHDRAWAL SYMPTOMS?

Tramal SR 100mg Tablet 10 'S tends to develop withdrawal symptoms in you as it centrally acts on the nervous system. It would help if you did not stop using it abruptly or should not deviate from the dosing schedule set by the prescriber. 

  • IS Tramal SR 100mg Tablet 10 'S SAFE TO USE IN PREGNANCY?    

It should be avoided in pregnancy as it may develop withdrawal symptoms in the neonate.                                                                             

  • CAN A BREASTFEEDING MOTHER TAKE Tramal SR 100mg Tablet 10 'S?

There is a risk of exposure of the infant to serious side effects associated with the use of Tramal SR 100mg Tablet 10 'S. So it should not be given to a breastfeeding mother as its active metabolite is secreted in breast milk.


Withdrawal symptoms may appear after 2 to 24 hours of the last dose. If the withdrawal symptoms are left untreated, they may persist for about 4 to 10 days. You should not suddenly stop taking Tramal SR 100mg Tablet 10 'S to avoid withdrawal symptoms. 

  • HOW TO STORE Tramal SR 100mg Tablet 10 'S?

Tramal SR 100mg Tablet 10 'S can be stored at room temperature, below 30ºC. Protect it from direct sunlight and moisture. 


Tramal SR 100mg Tablet 10 'S is taken for pain management and usually taken once daily. But if you miss the dose, take it whenever you remember throughout the day. 


The caregiver should look for breathing difficulties in case of overdose. Performing CPR (Cardiopulmonary Resuscitation) is helpful until the patient doesn’t get medical help. Naloxone is an active agent that reverses the effect of an opioid overdose. Medical practitioners give  Naloxone as an antidote to Tramal SR 100mg Tablet 10 'S toxicity.  

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1 Pack = 10 Tablet(s)
Rs. 302.47Rs. 343.72
12% off