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Tazdol 100mg/2ml Injection 5 vial is a synthetic opioid analog that produces pain suppression at the Central Nervous System (CNS) level. Tazdol 100mg/2ml Injection 5 vial is clinically prescribed to reduce moderate to severe pain in adults. It modifies the pain perception and response in the brain by acting as an agonist to the opioid receptors involved in analgesia.
Tazdol 100mg/2ml Injection 5 vial is also known to act as a serotonin reuptake inhibitor (SNRI) which makes it a potential agent to cause withdrawal symptoms in those who stop using it abruptly. This means that it also has anxiolytic and antidepressant effects to some extent so that Tazdol 100mg/2ml Injection 5 vial is an effective drug to be given to individuals who are suffering from depression and anxiety associated with pain.
Long-term use of Tazdol 100mg/2ml Injection 5 vial is associated with addiction that can lead to overdose and toxicity, especially when it is used along with other opioid analgesics and antidepressants. There is also a risk of serious breathing problems along with sleep apnea. That’s why the usual practice is to initiate the therapy with the least possible dose for the shortest possible time.
Tazdol 100mg/2ml Injection 5 vial also acts on certain pain modulators and inflammatory markers. This suggests that Tazdol 100mg/2ml Injection 5 vial has a broad spectrum of acting as a potent pain-killer which is why it is an effective supportive therapy in the management of neuropathic pain, osteoarthritic pain, fibromyalgia (muscular pain that involves whole-body), back pain, labor & post-operative pain, and pain associated with tumors.
Tazdol 100mg/2ml Injection 5 vial is indicated for managing moderate to severe pain in adults which could be chronic to severe. The extended-release formulation of Tazdol 100mg/2ml Injection 5 vial is used for long-term pain management. However, an immediate-release form is given for short-term pain management.
How Does Tazdol 100mg/2ml Injection 5 vial Work
Tazdol 100mg/2ml Injection 5 vial produces inhibitory effects on the ascending pain pathways by binding to the opioid mu receptors partially (agonistic effect) at the CNS level. Tazdol 100mg/2ml Injection 5 vial also weakly inhibits serotonin and norepinephrine reuptake. These neurotransmitters are involved in descending pain perception and Tazdol 100mg/2ml Injection 5 vial makes them available to produce descending pain modulation. This way, Tazdol 100mg/2ml Injection 5 vial works in synergism with the central nervous system for the modulation of pain perception and response.
Tazdol 100mg/2ml Injection 5 vial also produces analgesic effects by affecting other pain modulators in the CNS and markers of the inflammation involved in immune responses such as Prostaglandins E2, Cytokines, and Glial cells. This action aids in multiple clinical manifestations which require pain management as a supportive treatment such as osteoarthritis, labor, and postoperative pain.
How To Use Tazdol 100mg/2ml Injection 5 vial
Tazdol 100mg/2ml Injection 5 vial is a solution for injection that can be administered through IM (Intramuscularly) route or by slow IV (slow intravenous injection). It can also be diluted in solution to get administered for the patient-controlled analgesic effect. Intravenous injection of Tazdol 100mg/2ml Injection 5 vial should be administered slowly over 2 to 3 minutes.
Form and strength:
100mg injection (100mg/2ml)
It is recommended to select the lowest effective dose which may initiate analgesia. The dose should not be exceeded more than 400mg in a day.
The usual dose is 50 or 100mg given at 6 hours of intervals (4 times a day), IM, IV, IV infusion.
The initial dose for postoperative pain is 100mg, administered IV. A further 50mg is given after every 10 to 20 minutes within one hour of administration of the initial dose. This dosing procedure is continued until the total dose of 250mg is delivered to the patient’s bloodstream. Then the usual dosing schedule of 50 or 100mg is started 6 hourly until the desired response is achieved.
Tazdol 100mg/2ml Injection 5 vial should not be given to children below 12 years of age.
Tazdol 100mg/2ml Injection 5 vial is contraindicated to be used in pregnancy as it may cause withdrawal symptoms in the neonate. It may also cause respiratory depression in infants if administered to the mother during labor. Tazdol 100mg/2ml Injection 5 vial should not be taken by breastfeeding mothers as well as its active metabolite releases in breast milk and may harm the neonate.
The use of Tazdol 100mg/2ml Injection 5 vial is contraindicated in the following scenarios:
If you are sensitive to opioids, the active ingredients, the excipients used in the formulation of Tazdol 100mg/2ml Injection 5 vial.
If you have known or suspected obstruction in the G.I tract which may or may not be associated with gastrointestinal bleeding.
If you are taking Monoamine oxidase inhibitors (MAOIs) such as Isocarboxazid and Phenelzine, or have taken them in the last 14 days.
Children under 12 years of age or children under 18 years of age who have undergone surgery for the removal of tonsils or adenoids.
Severe or acute bronchial asthma, breathing problems, or respiratory depression.
Tazdol 100mg/2ml Injection 5 vial should be taken with caution under the following circumstances:
Taking higher doses than recommended increases the risk of seizures, especially in people who are on opioids or antidepressants.
Tazdol 100mg/2ml Injection 5 vial should be avoided in individuals who have suicidal tendencies or are prone to addiction.
Tazdol 100mg/2ml Injection 5 vial is known to develop an addiction. Its misuse may be fatal due to urge, leading to overdose and ultimately death due to respiratory depression.
Newborns may suffer from life-threatening withdrawal symptoms if Tazdol 100mg/2ml Injection 5 vial is administered during pregnancy.
Intake of alcohol during the treatment with Tazdol 100mg/2ml Injection 5 vial enhances slow breathing rate and hence causes fatal side effects. So consumption of alcohol or other sedatives should be strictly avoided.
If you feel extreme fatigue, loss of appetite, abdominal pain accompanied by nausea and vomiting, and low blood pressure; you should talk to your doctor as this may suspect adrenal insufficiency.
Tazdol 100mg/2ml Injection 5 vial can cause sleep-related breathing problems such as sleep apnea in which there is a breathing pause during sleep. It may also cause sleep hypoxemia in which the oxygen levels in the blood go low. If you feel symptoms like shortness of breath, waking up from a deep sleep due to a breathing problem, or disturbed sleeping patterns, you should immediately tell your doctor who might proceed with dose reduction or pause the treatment.
Tazdol 100mg/2ml Injection 5 vial is known to interact with some medications. Concomitant administration of them should be avoided:
Except for Alvimopan (compete for the receptor site), all other agents increase serotonin levels in the CNS and hence may put the patient at risk of Serotonin Syndrome.
Other agents that should be avoided during the treatment with Tazdol 100mg/2ml Injection 5 vial are:
Monoamine oxidase inhibitors (Phenelzine, Isocarboxazid)
Opioids (Buprenorphine, Nalbuphine)
Narcotics (Codeine, Morphine)
Benzodiazepines (Alprazolam, diazepam)
Tricyclic Antidepressants (Amitriptyline
Tazdol 100mg/2ml Injection 5 vial starts producing an analgesic effect within one hour of swallowing.
The duration of action of Tazdol 100mg/2ml Injection 5 vial is 9 hours.
You should not consume alcohol during or after a certain period of treatment as it may make you feel drowsy and enhance the chances of developing side effects such as breathing difficulty.
Tazdol 100mg/2ml Injection 5 vial tends to develop withdrawal symptoms in you as it centrally acts on the nervous system. It would help if you did not stop using it abruptly or should not deviate from the dosing schedule set by the prescriber.
It should be avoided in pregnancy as it may develop withdrawal symptoms in the neonate.
There is a risk of exposure of the infant to serious side effects associated with the use of Tazdol 100mg/2ml Injection 5 vial. So it should not be given to a breastfeeding mother as its active metabolite is secreted in breast milk.
Withdrawal symptoms may appear after 2 to 24 hours of the last dose. If the withdrawal symptoms are left untreated, they may persist for about 4 to 10 days. You should not suddenly stop taking Tazdol 100mg/2ml Injection 5 vial to avoid withdrawal symptoms.
Tazdol 100mg/2ml Injection 5 vial can be stored at room temperature, below 30ºC. Protect it from direct sunlight and moisture.
Tazdol 100mg/2ml Injection 5 vial is taken for pain management and is usually taken once daily. But if you miss the dose, take it whenever you remember throughout the day.
The caregiver should look for breathing difficulties in case of overdose. Performing CPR (Cardiopulmonary Resuscitation) is helpful until the patient doesn’t get medical help. Naloxone is an active agent that reverses the effect of an opioid overdose. Medical practitioners give Naloxone as an antidote to Tazdol 100mg/2ml Injection 5 vial toxicity.
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