Poze 15mg Tablet 14 'S

About

Poze 15mg Tablet 14 'S is an oral antidiabetic medication that is used to manage type 2 diabetes. Type-2 diabetes is non-insulin-dependent diabetes in which the insulin produced by the pancreas is less effective because the body doesn’t recognize it. Poze 15mg Tablet 14 'S being an oral antidiabetic agent, decreases insulin resistance and renders the body to make beneficial use of insulin in controlling diabetes. 

Poze 15mg Tablet 14 'S can be worsening in people with heart failure. Tell your doctor if you had congestive or any other type of heart failure in the past before starting the treatment with Poze 15mg Tablet 14 'S. Watch for symptoms like shortness of breath, edema, sudden weight gain, swollen ankles, tiredness, etc., after the initiation of treatment with Poze 15mg Tablet 14 'S. 

Lifestyle changes are advised along with the intake of Poze 15mg Tablet 14 'S, as exercise and proper diet play a role in controlling high blood sugar. Poze 15mg Tablet 14 'S on the other hand, acts by restoring the body’s response to insulin and helps lower blood sugar by making the pancreatic insulin useful. Poze 15mg Tablet 14 'S is often prescribed in combination with other oral antidiabetic agents such as glyburide, metformin, and sulfonylureas, depending on a person’s response to the treatment of hyperglycemia. 

Indications

Poze 15mg Tablet 14 'S is indicated in the individuals with type 2 diabetes as: 

• An adjunct to exercise and diet to enhance the body’s glycemic control 
• Monotherapy, specifically in overweight patients in which exercise and diet are not enough. Also, to whom Metformin is contraindicated or intolerant?
• Combination with metformin (dual therapy) for glycemic control or with sulfonylureas if Metformin is contraindicated or intolerant. 
• Triple therapy in combination with Sulphonylureas and Metformin in overweight patients who have insufficient glycemic control even despite the dual combination therapy with oral antidiabetic agents.  
• Combination with insulin when glycemic control is not sufficient in patients who are on insulin. 

How Does Poze 15mg Tablet 14 'S Work?

Poze 15mg Tablet 14 'S contains the active ingredient Pioglitazone which is responsible for causing insulin tissue sensitivity. Adipose tissue, skeletal muscles, and liver are the target sites for insulin’s action. These sites have Peroxisome proliferator-activated receptor gamma (PPARγ) that is involved in the insulin response. Poze 15mg Tablet 14 'S acts as a selective agonist to peroxisome proliferator-activated receptor gamma (PPARγ) at these insulin-acting sites and increases insulin-responsive genes transcription.

These insulin-responsive genes are involved in controlling the production, transport, and utilization of lipids and glucose. This way, the active ingredient - pioglitazone increases tissue sensitivity and decreases the hepatic production of glucose. This improves type 2 diabetes-associated insulin resistance without abnormal insulin secretion by the beta cells of the pancreas. 

How To Use Poze 15mg Tablet 14 'S?

Poze 15mg Tablet 14 'S is either used alone or in combination with other antidiabetic agents such as metformin, glyburide, and sulfonylureas. Poze 15mg Tablet 14 'S should be taken orally (by mouth) without regard to a meal.

Dosage

The active ingredient - Pioglitazone comes as an insulin sensitizer with the following strengths:

• 15mg tablet 
• 30mg tablet
• 45mg tablet 

Adult Dose

Type 2 Diabetes Mellitus

• As monotherapy or in combination with insulin or insulin secretagogue: 15 to 30 mg once daily with a meal. The dose can be increased by 15 mg with careful monitoring but should not exceed more than 45mg once a day (whether it's monotherapy or combination therapy). ALT (liver enzyme) should be monitored upon initiation of the therapy. The treatment continues once a month for 12 months, and then after every three months. 

The dose of insulin is decreased by 10 to 25% when administered with insulin if the patient has hypoglycemia or if the blood glucose levels go below 100mg/dL. The dose of insulin secretagogue (e.g. metformin, sulfonylurea) is decreased when administered in combination with these agents if the patient reports hypoglycemia. 

Pediatric Dose

Poze 15mg Tablet 14 'S is not indicated for use in children.

Pregnancy And Lactation

The mechanism of action of Poze 15mg Tablet 14 'S is not clear in pregnant women, and neither the active component is known to be secreted in human milk. Therefore, Poze 15mg Tablet 14 'S is not recommended for use in pregnant and lactating females. 

Contraindications

Poze 15mg Tablet 14 'S is contraindicated in the following cases:

• Hypersensitivity to the active agent or excipients. 
• Symptomatic cardiac failure or history of any type of cardiac failure.
• Moderate to severe liver Impairment 
• Diabetic Ketoacidosis (lack of insulin to allow the entry of blood sugar into the cells to use energy)
• Bladder cancer or active renal symptoms (e.g., blood in urine) 
• Active osteoporosis or osteopenia (bone diseases) 

Precautions

Caution should be taken with the use of Poze 15mg Tablet 14 'S in the following cases:

• Poze 15mg Tablet 14 'S puts a person at risk of congestive heart failure upon the initiation of therapy or after increasing the doses. The patient should be closely observed for the symptoms of heart failure, such as rapid weight gain, edema, shortness of breath, etc. Dose reduction or discontinuation of therapy with Poze 15mg Tablet 14 'S should be considered if these symptoms are visible. 
• As Poze 15mg Tablet 14 'S its insulin-sensitizing effect only in the presence of insulin, it is not for use in people with type 1 diabetes or diabetic ketoacidosis.
• If you are taking Poze 15mg Tablet 14 'S in combination with other antidiabetic agents, their dose reduction is necessary as administering the combination may put you at risk of hypoglycemia. 
• Poze 15mg Tablet 14 'S has the potential to decrease the levels of hemoglobin and hematocrit. So routine monitoring of hematocrit helps assess present side effects. 
• People with active liver disease or elevated liver enzymes should not use Poze 15mg Tablet 14 'S as it tends to elevate liver enzymes.
• People who have mild elevation in their liver enzymes should initiate or continue the treatment with Poze 15mg Tablet 14 'S cautiously with routine monitoring and clinical follow-ups. 
• Poze 15mg Tablet 14 'S has the potential to cause weight gain, but it is dose-related. Dietary changes would help to cope with obesity. 
• Poze 15mg Tablet 14 'S has the potential to cause blurred vision and macular edema (building up of fluid in the macula of the eye). Routine examination with the ophthalmologist is advised. 
• Females who are on Poze 15mg Tablet 14 'S are more vulnerable to the risk of fractures. 
• Geriatrics are at increased risk of the incidence of bone fracture and heart failure. 

Interactions With Other Medications

Following medications interfere with the metabolism of Poze 15mg Tablet 14 'S and show interaction:

• Rifampicin
• Midazolam
• Baricitinib
• Gemfibrozil
• Ethanol
• Eluxadoline

Your healthcare provider must know if you are on these drugs or have recently consumed them before the initiation of therapy. 

Adverse Effects

Common Side Effects 

• Hypoglycemia (low blood sugar)
• Edema (specifically when used in combination with insulin or sulfonylurea)
• Upper respiratory tract infection
• Weight gain

Less Common Adverse Effects 

• Anemia
• Visual disturbances
• Hematuria
• Headache
• Flatulence
• Dizziness
• Increase in blood creatinine phosphokinase
• Joint and back pain 
• Hypoaesthesia (partial or total loss of sensation in a body part)
• Shortness of breath
• Risk of heart failure

Rare Adverse Effects

• Vertigo 
• Increase in lactic dehydrogenase enzyme
• Enhanced appetite 
• Proteinuria (Excretion of protein in urine)
• Glycosuria (Excretion of glucose in the urine)
• Excessive sweating 

How To Cope with Some of The Adverse Effects

• Hypoglycemia- You can cope with the symptoms of hypoglycemia by taking 15 to 20 g of fast-acting carbohydrates. Fast-acting carbohydrates have sugar content without protein and fat, so they are easily converted into sugar, once inside your body. Stay in a resting position and drink fruit juice, and glucose tablets to help cope with low blood sugar. 
• Weight gain - Weight gain can be controlled by lowering the dose of medicine, eating in little portions, avoiding high calories alcoholic beverages, increasing physical activity such as walking & exercise, and increasing protein intake. Protein will make you feel fuller for a long time. You can also limit weight gain by limiting salt intake i.e., consumption of fewer than 2000 mg of salt per day.
• Anemia - Pale skin, fatigue, weakness, and disturbed appetite are signs of anemia. Eat iron-rich food such as beef, salmon, cereals, liver, dry fruits, and leafy vegetables. Take a good night's sleep, take rest when needed to avoid fainting, and light exercise daily improves blood flow. 
• Dizziness - Do not get up or change your position immediately when you are feeling dizzy. Instead, get up slowly and steadily. Increase your fluid intake to stay energetic, and refrain from coffee, smoking, alcohol, and addicting drugs. 

FAQs

Q. HOW DOES Poze 15mg Tablet 14 'S PRODUCES ITS ANTIDIABETIC EFFECT?

Poze 15mg Tablet 14 'S is a “glitazone” oral antidiabetic agent that controls high blood sugar by making your body sensitive to insulin. This way, your tissues make use of insulin in lowering blood glucose. 

Q. HOW LONG DOES IT TAKE Poze 15mg Tablet 14 'S TO PRODUCE ITS EFFECTS?

It takes a few weeks to lower the blood sugar levels. Poze 15mg Tablet 14 'S helps maintain a stable sugar level and this way, it prevents developing diabetes-associated problems in the future. 

Q. WILL I EXPERIENCE HYPOGLYCEMIA AS A SIDE EFFECT OF Poze 15mg Tablet 14 'S?

Poze 15mg Tablet 14 'S if taken alone, does not tend to cause hypoglycemia. However, low blood sugar can occur because of combination therapy. The dose of a combined insulin sensitizer (e.g metformin, Sulphonylureas) is reduced if there is hypoglycemia. 

Q. DOES THE USE OF Poze 15mg Tablet 14 'S PUT ME AT A RISK OF HEART FAILURE?

Poze 15mg Tablet 14 'S has the potential to put a person at risk of heart failure but in those who are above 65 years of age. Also, the tendency of this side effect increases if administered with insulin. You should not take Poze 15mg Tablet 14 'S if you had gone through any type of heart failure in the past.  Also, watch yourself for shortness of breath, edema, and swollen legs. These symptoms suspect heart failure. 

Q. CAN Poze 15mg Tablet 14 'S BE TAKEN BEFORE SURGERY?

Tell your doctor if you are taking Poze 15mg Tablet 14 'S along with other antidiabetic agents or with insulin. Because, if there is hypoglycemia, it will be difficult to distinguish between anesthesia and hypoglycemia after surgery. Your doctor might reduce your insulin dose before surgery. 

Q. DO LIFESTYLE CHANGES AID IN MANAGING DIABETES?

You can maintain your body for glycemic control by taking a balanced & healthy diet, doing regular exercise, quitting smoking, and refraining from alcohol. Poze 15mg Tablet 14 'S is usually prescribed along with a suggested diet and exercise when these two factors alone are not enough to control high blood sugar. 

Q. CAN Poze 15mg Tablet 14 'S MAKE ME FAT?

Use of Poze 15mg Tablet 14 'S is associated with weight gain. A healthy and balanced diet along with regular exercise keeps your body in shape. Poze 15mg Tablet 14 'S also causes water retention in the body. So, if you feel that your ankles are swollen, and there is shortness of breath, it’s time to visit your doctor. 

Q. IS THERE ANY FOOD I NEED TO AVOID?

Since you need to avoid food with high sugar content, you can check the nutrition labels on the products to see if they suit you. You should avoid fizzy drinks, sweets, chocolates, and cakes. Along with that, you need to keep fast-acting carbohydrates with you such as fruit juices, and sugar cubes for aid if your blood sugar level drops. 

Q. CAN I GO ON A RIDE AFTER TAKING Poze 15mg Tablet 14 'S?

It depends on the glycemic control of your body. You can drive a vehicle and lift heavy machinery if your blood sugar levels are stable with the use of Poze 15mg Tablet 14 'S. But if you are taking other antidiabetic medications, this puts you at risk of getting hypoglycemic episodes. Monitor your blood glucose frequently and then decide to go on a ride. 

Q. CAN A PREGNANT OR NURSING MOTHER TAKE Poze 15mg Tablet 14 'S?

The mode of action of Poze 15mg Tablet 14 'S is not known in a childbearing woman, nor the active component is known to be secreted in human milk. Therefore, its use is not recommended in pregnant or lactating women. 

Q. WHAT ARE THE STORAGE CONDITIONS OF Poze 15mg Tablet 14 'S?

Store Poze 15mg Tablet 14 'S at room temperature, between 25°C to 30°C, and protect it from moisture and direct sunlight.