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Maxolon 5mg/5ml Syrup 50 ml

Prescription Required

FORMULAMetoclopramide HCl 5 mg / 5 ml
COMPANYGSK Consumer Healthcare


{{Product}} is an antiemetic drug that is majorly used to treat nausea and vomiting associated with Gastroesophageal Reflux Disease (GERD), chemotherapy, and Gastroparesis (slow stomach emptying in diabetics). {{Product}} is also prescribed in the management of migraine, and administered along with pain killers to increase their efficacy.

{{Product}} works by increasing gastric motility in the upper intestinal region and thereby raises the gastric emptying rate. The prokinetic (control of gastroesophageal reflux) effect takes place by blocking dopamine (a neurotransmitter that induces nausea and vomiting). 

There is a warning associated with Maxolon 5mg/5ml Syrup 50 ml that is “Tardive Dyskinesia”. {{Product}} should not be taken for more than 12 weeks to minimize the risk of developing Tardive Dyskinesia - a neurological disorder characterized by involuntary jerky movements of muscles, specifically in the head and neck region. Due to the risk of this serious side effect, Maxolon 5mg/5ml Syrup 50 ml is not recommended to be given to children who are younger than 1 year of age. 


The healthcare providers prescribe Maxolon 5mg/5ml Syrup 50 ml in the following symptoms:

  • Chemotherapy-induced nausea and vomiting

  • Migraine associated nausea and vomiting

  • Prevention of radiotherapy-induced nausea and vomiting

  • Gastroesophageal reflux disease 

  • Diabetic Gastroparesis (Slow stomach emptying rate characterized by heartburn and discomfort)

How Does Maxolon 5mg/5ml Syrup 50 ml Work

{{Product}} inhibits Dopamine (D2) and Serotonin (5HT-3) receptors in the brain (at the chemoreceptor trigger zone - responsible for emesis). Along with this, Maxolon 5mg/5ml Syrup 50 ml acts as an agonist to 5HT-4 receptors that in turn increases the release of acetylcholine. This leads to a rise in gastric transit through the gut and the gastric emptying action takes place by lowering the pressure of the lower esophageal sphincter. This action doesn’t involve any gastric secretions. This way, {{product}] acts as a peristaltic stimulant and produces anti-emetic effects. 

Dopamine is responsible for relaxing the gastric smooth muscles. Maxolon 5mg/5ml Syrup 50 ml opposes this effect by inhibiting the dopaminergic effect and increasing the cholinergic effect. The relaxing action takes place at the same time at the upper region of the small intestine so that the antrum and upper region of the small intestine coordinate in lowering the reflux. 

How To Use Maxolon 5mg/5ml Syrup 50 ml

  • Take the suggested dose of Maxolon 5mg/5ml Syrup 50 ml from a syringe (for accuracy) or teaspoon as per the physician’s recommendation. 

  • {{Product}} is normally administered half an hour before a meal and at bedtime as per the doctor’s instructions. 

  • Do not take Maxolon 5mg/5ml Syrup 50 ml in larger doses than recommended as there is a risk of developing a movement disorder as an adverse effect associated with long-term use or overdose of Maxolon 5mg/5ml Syrup 50 ml. 


Form and strength:

  • Syrup: 5mg/5ml

  • Tablet: 10mg 

  • IV and IM injection: 10mg/2ml 

Adult Dose

10mg (2 teaspoons full) three times a day is the recommended dose generally given to adults and the duration of treatment is 5 days. The dose should be reduced for adults who weigh less than 60 kgs and for those who have significant renal or hepatic diseases. 

Diabetic Gastroparesis

10mg after every six hours (2 teaspoons full four times a day) 30 minutes before meals and at bedtime for 2 weeks to 8 weeks, depending on the patient’s condition. 

Gastroesophageal Reflux Disease

10 to 15 mg (2 to 3 teaspoons full respectively) after every six hours, 30 minutes before meals, and at bedtime, depending on the response to the drug. The dose should not be more than 80 mg in one day and treatment should not be exceeded to more than 12 weeks. 

Pediatric Dose

  • {{Product}} is not recommended for use in children below 1 year of age.

  • {{Product}} is prescribed 3 times a day, according to the child's body weight as: 


Weight (kgs)

Recommended Dose

10-14 kg

1 mg (1ml)

15-19 kg

2 mg (2ml)

20-29 kg

2.5 mg (2.5ml)

30-60 kg

5 mg (5ml)

Over 60 kg

10 mg (10ml)


Prevention Of Delayed Chemotherapy-Induced Nausea and Vomiting

0.1 to 0.15 mg/kg is the recommended dose that is repeated up to three times a day.

Pregnancy And Lactation 

{{Product}} crosses the placenta so it can cause extrapyramidal symptoms and methemoglobinemia in the infant. Breastfed neonates have gone through stomach upsets whose mothers were on Maxolon 5mg/5ml Syrup 50 ml. The infant should be closely observed for any signs of dystonia (twitching of muscles) and other significant clinical signs which may reflect adverse reactions. 


{{Product}} is contraindicated or in the following cases:                 

  • Known hypersensitivity to the excipients or the active agent.  

  • Within the first 4 days of certain procedures like gut anastomosis and Pyloroplasty (a surgery in which the lower region of the stomach is operated to make it wide). 

  • Perforation or active bleeding in the G.I tract. 

  • In children younger than 1 year of age due to the risk of extrapyramidal disease (involuntary movement of muscles). 

  • Pheochromocytoma (tumor of the adrenal gland) can lead to serious hypertension. 

  • History of epilepsy or Parkinson’s disease.

  • History of inherited blood diseases like Methamoglobinaemia, or NADH cytochrome B5 deficiency. 

  • If you are taking red yeast rice as Maxolon 5mg/5ml Syrup 50 ml increases its effects and there is a risk of myopathy. 

  • If you are on antipsychotics as there is a risk of extrapyramidal effects (movement disorder).  


Following are the points your doctor should know before starting the treatment with Maxolon 5mg/5ml Syrup 50 ml:

  • If you are pregnant or trying to get pregnant, or if you are a breastfeeding mother as {[product}} crosses the placental barrier. The infant should be monitored for the potential adverse effects if the mother has to take Maxolon 5mg/5ml Syrup 50 ml. 

  • If there are signs of tardive dyskinesia (involuntary muscle movements), stop using Maxolon 5mg/5ml Syrup 50 ml immediately. 

  • The treatment should not be continued longer than 12 weeks as there is a high risk of tardive dyskinesia with long-term use. 

  • It should be used with caution in people having a history of any mental illness. 

  • {{Product}} should be used with caution in cardiovascular and renal diseases as it may cause Q.T prolongation (extension between the contraction and expansion of myocardial muscles which may cause abnormal heart rhythms). 

  • Monitor your blood sugar regularly if you are diabetic and inform your doctor if you find any notable changes. 

Interactions With Other Medications

Tell your doctor if you are on the following drugs before starting treatment with Maxolon 5mg/5ml Syrup 50 ml:

  • Antipsychotics (Lurasidone, aripiprazole)

  • MAO Inhibitors (Linezolid, Phenelzine)

  • Dopamine agonists (e.g. ropinirole)

  • Antiparkinson’s drugs (e.g. Levodopa)

  • Fosfomycin

  • Phenothiazines (e.g promethazine)

  • Rivastigmine

  • Sedatives

  • Digoxin

  • Cyclosporine

Some drugs may increase serotonin levels when co-administered with Maxolon 5mg/5ml Syrup 50 ml that can lead to extrapyramidal reactions and risk of serotonin syndrome. These include:

  • Duloxetine

  • Sertraline 

  • Citalopram

  • Paroxetine

  • Desvenlafaxine

Adverse Effects

Common Adverse Effects

Following are the common adverse effects associated with the usage of Maxolon 5mg/5ml Syrup 50 ml.

  • Drowsiness

  • Weakness 

  • Tremor

Potential Adverse Effects 

  • Abnormal muscle movements especially of the head and neck region (Tardive dyskinesia) followed by high doses or long-term use. 

  • Neuroleptic malignancies such as increased salivation, excessive sweating, etc. 

  • Increased prolactin levels 

Rare Adverse Effects

  • Convulsions

  • State of confusion 

How To Cope With Some Of The Adverse Effects

  • Drowsiness - Drowsiness is the common side effect of Maxolon 5mg/5ml Syrup 50 ml can be managed by quitting driving for a while, stopping lifting heavy machinery, and minimizing alcohol consumption. 

  • Tremor- If you are having involuntary jerky movements, you should immediately tell your doctor. He might stop Maxolon 5mg/5ml Syrup 50 ml due to the risk of potential side effects of extrapyramidal symptoms. 

  • Weakness - Lying down in a comfortable position for a while and a break from work may help cope with this side effect. 

Key Facts About Maxolon 5mg/5ml Syrup 50 ml

  • {{Product}} is taken only for a short period. Prolonging the dose than recommended may lead to serious adverse effects i.e. Tardive Dyskinesia.

  • As drowsiness is a common side effect of Maxolon 5mg/5ml Syrup 50 ml, you should not drink alcohol during the treatment to prevent dizziness. 

  • Maxolon 5mg/5ml Syrup 50 ml is taken only for a short period (as per the doctor’s suggestion). Prolonging the duration of treatment may lead to a serious adverse effect i.e. Tardive Dyskinesia. 

  • Treatment should not be continued for more than 12 weeks. 

  • As drowsiness is a common side effect of Maxolon 5mg/5ml Syrup 50 ml, you should avoid drinking alcohol during the treatment to prevent dizziness. 


  • What if I miss the dose?

If you miss the dose, you should take it when you remember but you should keep the dosing interval in mind. If the time for the next dose is near, you should skip the previous one and continue taking Maxolon 5mg/5ml Syrup 50 ml as prescribed. 

  • Can I consume alcohol during the treatment?

No, Maxolon 5mg/5ml Syrup 50 ml is associated with a common side effect that is drowsiness. Consumption of alcohol or any sedatives may worsen the side effects. 

  • Can I take anti-allergic medicines along with Maxolon 5mg/5ml Syrup 50 ml?

You should take them after discussing them with the doctor. He might prescribe you an antiallergic that is less sedating. He may also set suitable dosing intervals at which the Maxolon 5mg/5ml Syrup 50 ml may not interact with the antiallergic drug. 

  • I am a breastfeeding mother, can I take {{metoclopramide}}?

It is not recommended to take Maxolon 5mg/5ml Syrup 50 ml by a breastfeeding mother as a certain amount of drug is secreted in breast milk and can pose undesirable effects on the baby. 

  • Can I drive when I am on Maxolon 5mg/5ml Syrup 50 ml?

Yes, you can. But you should stop driving if you start feeling dizzy and continue it after the completion of the dose. 

  • Are there any dietary limitations associated with the use of Maxolon 5mg/5ml Syrup 50 ml?

You can take any sort of food unless your doctor hasn't specified any limitations. However, Maxolon 5mg/5ml Syrup 50 ml is taken on an empty stomach (30 minutes before a meal). 

  • How should I store {{product}]?

You should keep the container tightly closed after usage. Keep it in a place where it remains protected from direct sunlight and moisture. You can store Maxolon 5mg/5ml Syrup 50 ml at room temperature. 

  • Can contraception be affected by the use of Maxolon 5mg/5ml Syrup 50 ml?

{{Product}} doesn’t render any direct effects on contraception. However, contraceptive pills may fail to produce their effect if you develop severe diarrhea due to enhanced gastric motility. 


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1 Pack = 50ml Syrup(s)
Rs. 42.95Rs. 48.81
12% off