Flagyl 200mg/5ml Suspension 90 ml

About 

Flagyl 200mg/5ml Suspension 90 ml is an antimicrobial that is used for the prevention and treatment of serious anaerobic (bacteria that can survive in the absence of oxygen) bacterial infections specifically those which are caused by Clostridia, Streptococci, Bacteroides, etc. Flagyl 200mg/5ml Suspension 90 ml kills parasites and bacteria that cause infection in the genital tract,  pelvis, stomach, intestine, teeth, and gums. It is also used to treat pressure sores and leg ulcers. Prescribers usually recommend Flagyl 200mg/5ml Suspension 90 ml if anaerobic bacteria are the suspected pathogens for a certain infection. 

Indications

Flagyl 200mg/5ml Suspension 90 ml is indicated when there are:

• Infections due to anaerobic pathogens 
• Dysentery due to anaerobic bacteria
• Abscess of liver
• Trichomoniasis infection 
• Amoebic infections
• Acute ulcerative gingivitis
• Non-specific vaginal infections
• Leg ulcers and pressure sores (due to anaerobic bacteria)
• Infections due to H.Pylori (in children)
• Giardiasis
• Post-operative infections due to Bacteroides and anaerobic streptococci

How Does Flagyl 200mg/5ml Suspension 90 ml Work

Flagyl 200mg/5ml Suspension 90 ml has “Metronidazole” as an active therapeutic agent. It contains a nitro group in its structure that is reduced to a chemically active form in the hypoxic cells (cells with a lack of oxygen) or when anaerobes are around. This active component causes biochemical lesions in the cells and causes cell death. Metronidazole produces its action in the DNA of an anaerobic bacterial cell by causing the loss of DNA helical structure and inhibiting synthesis. 

How To Use Flagyl 200mg/5ml Suspension 90 ml

Take the 1 to 2 teaspoons full orally (by mouth) with or without meal according to the recommended dosing schedule which is usually 2 to 3 times a day. Avoid using alcohol during the treatment and 3 days after having the last dose. 

Dosage

Adult Dose

Adults and children over 10 years of age: 10ml (2 teaspoons full) with 8 hours of interval. The usual duration of treatment is 7 days depending upon the severity of the infection.  

Pediatric Dose

The pediatric dose depends upon the weight of a child. The dose is given after every 8 to 12 hours depending on the age of the child. Flagyl 200mg/5ml Suspension 90 ml will be administered 2 to 3 hours before surgery to prevent the occurrence of infection after surgery. 

Children more than 8 weeks to 12 years of age: 20 to 30 mg/kg as a single dose or divided 8 hourly as 7.5 mg/kg. The dose can be increased to 40 mg/kg depending on the seriousness of the infection. 7 days is the usual duration of treatment.

For children below 8 weeks of age: 15 mg/kg as a single dose given once a day or divided as 7.5 mg/kg to be given after every 12 hours.  

Pregnancy And Lactation

Flagyl 200mg/5ml Suspension 90 ml is not recommended in pregnancy and lactation. 

Contraindications

• Hypersensitivity to the active agent or excipients
• Pregnant women
• Severe hepatic disease or injury
• People undergoing dialysis
• If you have taken disulfiram within the past two weeks
• Cockayne syndrome (a rare disease in which there is delayed development, failure to gain weight, and small size of the head).

Precautions

• The patient should not use alcohol during (at least 48 hours) of the treatment and within 3 days due to the potential risk of disulfiram-like illness i.e., developing nausea, vomiting, abdominal cramps, headache, and flushing.
• There is a need for re-administering Flagyl 200mg/5ml Suspension 90 ml after dialysis because the active agent and its metabolites are removed during eight hours of dialysis.
• People with hepatic encephalopathy may develop toxicity due to the accumulation of the active constituent, metronidazole. So Flagyl 200mg/5ml Suspension 90 ml should be administered only once daily or may be reduced to one-third in people with hepatic encephalopathy.
• The current or chronic CNS disease may get aggravated. Therefore, Flagyl 200mg/5ml Suspension 90 ml should be given with caution to patients with CNS disease.
• Hepatotoxicity and acute liver failure can occur in people with Cockayne syndrome (a rare disease characterized by a small-sized head, delayed development, and growth). Flagyl 200mg/5ml Suspension 90 ml should be used in such population only if no other alternative is available and after assessing the benefits over risk.
• Treatment with Flagyl 200mg/5ml Suspension 90 ml should immediately be discontinued if there are symptoms of severe skin conditions such as  Stevens-Johnson syndrome and Toxic Epidermal Necrolysis. 

Interactions With Other Medications

Flagyl 200mg/5ml Suspension 90 ml shows interactions with:

• Anticoagulants (e.g., warfarin)
• Phenobarbital
• Phenytoin 
• Lithium 
• Alcohol 
• Disulfiram (psychotic reactions)

The toxicity of the following drugs is increased if taken with Flagyl 200mg/5ml Suspension 90 ml, so concomitant administration is contraindicated:

• Lomitapide
• Lonafarnib
• Dronabinol
• Flibanserin
• 5-fluorouracil

Adverse Effects

Common Adverse Effects 

• Peripheral neuropathy
• Nausea and vomiting 
• Confusion 
• Headache
• Dyspepsia 
• Urticaria 
• CNS depression 
• Angioedema 
• CNS disturbances 
• Dark urine 

Less Common Adverse Effects 

• Metallic taste
• Dizziness
• Genital pruritus 
• Diarrhea 
• Upper respiratory tract infections 
• Flu-like symptoms 

Rare Adverse Effects

Transient leukopenia and neutropenia

How To Cope with Some of The Adverse Effects

• Dyspepsia - Drink plenty of water and increase the intake of vegetables like mint and ginger. Avoid smoking and alcohol intake. Do not lie down immediately after having a meal.
• Headache -  Using a cold pack or hot compress helps in relieving headaches, and caffeine helps reduce pain, you can also take an over-the-counter analgesic medication if pain persists.
• Nausea -  Take small and frequent meals and avoid taking heavy meals. Stay in the fresh air, chew peppermint gum, or take peppermint tea. You can also take an anti-emetic if there are episodes of vomiting, after discussing it with your doctor.
• Dizziness- You can cope with dizziness by taking a good sleep. Stop vigorous work if you feel lightheaded. Do not lift heavy weights and avoid taking rides. Usage of alcohol and caffeine should be avoided.
• Flu-like Symptoms - Alcohol can worsen jaundice, so avoid drinking alcohol along with smoking cessation. Also, maintaining healthy weight and cholesterol levels, drinking enough water, and sun exposure are the practices that help cope with Jaundice. Moreover, taking a healthy diet such as reddish juice and basil leaves also helps deal with jaundice. 

FAQs

Q1. HOW DOES Flagyl 200mg/5ml Suspension 90 ml WORK?

Flagyl 200mg/5ml Suspension 90 ml works by causing lesions in the anaerobic bacterial or parasitic cell due to which, its DNA helical structure is destructed, and synthesis of new DNA is inhibited. 

Q2. CAN I DRINK ALCOHOL DURING THE TREATMENT WITH Flagyl 200mg/5ml Suspension 90 ml?

Alcohol consumption is contraindicated during the treatment and within at least 48 hours of finishing the course. Alcohol intake during the treatment can cause symptoms like nausea, vomiting, headache, stomach pain, flushing, and palpitations.

Q3. DOES Flagyl 200mg/5ml Suspension 90 ml TEND TO AFFECT SEXUAL ACTIVITY?

Flagyl 200mg/5ml Suspension 90 ml doesn’t usually affect sexual activity unless a person is being treated for trichomonas infection. A contraceptive should be used, or intercourse should be avoided in that case. 

Q4. CAN A PREGNANT OR NURSING MOTHER TAKE Flagyl 200mg/5ml Suspension 90 ml?

Flagyl 200mg/5ml Suspension 90 ml is passed in the breast milk, which may cause harm to the baby’s stomach. So, it should be avoided by a nursing mother unless clinically necessary. Also, a pregnant woman should not use Flagyl 200mg/5ml Suspension 90 ml due to the potential risk of side effects to the fetus. 

Q5. WHAT ARE THE STORAGE CONDITIONS OF Flagyl 200mg/5ml Suspension 90 ml?

Flagyl 200mg/5ml Suspension 90 ml should be stored at room temperature, away from moisture and direct sunlight. It should not be frozen. 

Q6. CAN I DRIVE A BIKE AFTER USING Flagyl 200mg/5ml Suspension 90 ml?

You can drive a bike while taking Flagyl 200mg/5ml Suspension 90 ml unless you do not feel dizzy or weak. Antimicrobials usually cause weakness and drowsiness as side effects. So, it is better to avoid driving if you are having such side effects.

Q7. WHAT IF I MISS THE DOSE?

Take the dose as soon as you remember unless it is almost time for the next dose. You can skip a dose if the time for the next dose is near, to avoid exceeding the dose limit in a day. 

Q8. CAN I STOP TAKING Flagyl 200mg/5ml Suspension 90 ml ABRUPTLY?

Flagyl 200mg/5ml Suspension 90 ml doesn't cause withdrawal symptoms but it should be taken as long as your doctor tells you to take it. If you do not complete the duration of therapy as per the prescription, the infection may reappear.