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Dulan 60mg Capsule 10 'S is an antidepressant that belongs to the class Selective Serotonin Norepinephrine Reuptake Inhibitors (SSNRIs) which work by blocking the reuptake of serotonin and norepinephrine (neurotransmitters) and thereby increase their availability in the Central Nervous System. These two neurotransmitters cease the signaling of pain at the neuronal level. So their availability is required for pain management as well. Dulan 60mg Capsule 10 'S is used for mood elevation, fibromyalgia (pain in muscles leading to lethargy), anxiety associated with pain, diabetic neuropathy (pain and tingling sensations in hands and feet), chronic joint and muscles pain (osteoarthritis), and sometimes in urine incontinence in women (involuntary passage of urine during daily activities like laughing and sneezing).
Dulan 60mg Capsule 10 'S can be given to adults and children older than 7 years of age, who are facing excessive stress for the past 6 months. Dulan 60mg Capsule 10 'S is considered as a first-line agent in the management of chronic anxiety, especially for those who develop dependency. Withdrawal symptoms may appear if the treatment is ceased abruptly. The healthcare practitioners gradually reduce the dose of Dulan 60mg Capsule 10 'S rather than stopping the dose at once.
If a person stops taking Dulan 60mg Capsule 10 'S abruptly, he may suffer from withdrawal symptoms such as anxiety, headache, numbness in hands, fatigue, dizziness, nausea, vomiting, diarrhea, sweating, and disturbed sleeping patterns. Dulan 60mg Capsule 10 'S renders a symptomatic treatment to major depressive disorder. It may take 1 to 4 weeks or more to show beneficial effects. Whenever you feel such symptoms after a reduction in the dose of Dulan 60mg Capsule 10 'S, you should consult your doctor.
Dulan 60mg Capsule 10 'S is a prescription-only medicine that is indicated by a medical practitioner to treat the following conditions:
Dulan 60mg Capsule 10 'S works by selectively inhibiting the reuptake of two neurotransmitters in the central nervous system i.e. Serotonin and Norepinephrine. This way, Dulan 60mg Capsule 10 'S balances the availability of Serotonin and Norepinephrine which become imbalanced in a person suffering from depression and other aforementioned conditions. Depending on the dose, the extracellular levels of serotonin and norepinephrine are raised to reduce the threshold of pain, whether it is inflammatory or neuropathic.
Dulan 60mg Capsule 10 'S also weakly blocks the reuptake of dopamine (a neurotransmitter in the brain responsible for reward-motivated behavior) and thereby works as a mood elevator. Dulan 60mg Capsule 10 'S doesn’t show any significant receptor-mediated adverse effects because of the lack of binding affinity with cholinergic, dopaminergic, histaminergic, and adrenergic receptors.
Dulan 60mg Capsule 10 'S is taken orally (by mouth) and should not be crushed or chewed. Do not sprinkle the inner contents of the capsule on food. Doing this may affect the enteric coating of Dulan 60mg Capsule 10 'S that in turn affects the absorption rate. Dulan 60mg Capsule 10 'S can be administered with or without a meal, but absorbs well on an empty stomach.
The dose should be gradually reduced (over 1 to 2 weeks) rather than abrupt discontinuation. Otherwise, intolerable symptoms may appear. Minor withdrawal symptoms may also occur upon starting the reduced dose. Consult your doctor in that case. Your doctor might continue treatment with the previous dose or gradually follow dose redu. The treatment is usually started with a low dose that is gradually increased after a week and is ended by slowly tapering off.
Dulan 60mg Capsule 10 'S is available as a delayed-release capsule (a therapeutic agent is released in the intestine) to be administered orally (by mouth).
Forms and strength:
Dulan 60mg Capsule 10 'S 20mg capsule
Dulan 60mg Capsule 10 'S 30mg capsule
Dulan 60mg Capsule 10 'S 60mg capsule
Major Depressive Disorder
The lowest starting dose is 30mg once daily that can, increasing daily after a week as a maintenance dose.
Generalictionzed Anxiety Disorder
Diabetic Peripheral Neuropathy
Patients with diabetic neuropathy are treated with 60mg once daily dose which can be increased to 60mg twice daily if results are insufficient. The response is monitored after every two months of therapy.
60mg once daily is the recommended dose for Fibromyalgia after keeping the patient on 30mg once daily for the first week of treatment.
Stress urinary incontinence
The recommended initial dose is 20mg once daily that is switched to 20mg four times a day after 2 weeks of treatment.
Chronic Musculoskeletal Pain
The dose should not be exceeded more than 60mg once a day. Initial therapy is 30mg once daily.
If Creatinine Clearance is less than 30 ml/min in a renal impaired patient, usage of Dulan 60mg Capsule 10 'S should be avoided.
Dulan 60mg Capsule 10 'S should be avoided in late pregnancy as postpartum hemorrhage is seen. However, Dulan 60mg Capsule 10 'S is safe to be administered in lactating mothers. There is no significant clinical data available that points to the safety of Dulan 60mg Capsule 10 'S in pregnancy.
Tell your doctor if you are on the following drugs before starting treatment with Dulan 60mg Capsule 10 'S:
Common Adverse Effects
These mild to moderate adverse effects tend to decrease with time depending on the treatment.
Rare Adverse Effects
How To Cope With Some Of The Adverse Effects
Key Facts About Dulan 60mg Capsule 10 'S
Q. Can a patient of depression with physical injury (such as a car accident) take Dulan 60mg Capsule 10 'S?
Yes, he can. Dulan 60mg Capsule 10 'S is prescribed for depression accompanied by pain. But it can be taken upon the advice of a medical practitioner.
Q. What if I miss the dose?
In case you miss the dose, take it when you remember. You can skip the dose if it's time for the next dose.
Q. What to do if a change in dose is intolerable?
If you are experiencing intolerability after dose reduction, tell your doctor. He might switch you to the previous dose and dose reduction and more gradually dose reduction will be done
Q. Will dizziness occur while taking Dulan 60mg Capsule 10 'S?
Dizziness is common during the initial phase of treatment or when the dose is increased. Do not immediately get out of bed or immediately stand up. Practice this slowly and steadily by resting your feet on the floor for a few seconds.
Q. How do hypertensive patients respond to Dulan 60mg Capsule 10 'S?
Dulan 60mg Capsule 10 'S causes a rise in blood pressure. So Dulan 60mg Capsule 10 'S should not be taken until and unless your doctor doesn’t recommend it. He may start therapy after closely monitoring your blood pressure and suggesting hypertensive medicines in sufficient doses. Monitor your blood pressure daily if you are hypertensive.
Q. What are the recommended storage conditions of Dulan 60mg Capsule 10 'S?
Store Dulan 60mg Capsule 10 'S in a dry place at 25 °C and protect it from direct contact with the sunlight. If traveling, it can be stored at a temperature from 15°C to 30°C.
Q. Is Dulan 60mg Capsule 10 'S safe to use in pregnancy?
There are not any specific recommendations regarding the intake of Dulan 60mg Capsule 10 'S in pregnancy and lactation. However, if you were taking Dulan 60mg Capsule 10 'S before getting pregnant, you need to talk to your doctor. If taken in the last month of pregnancy, Dulan 60mg Capsule 10 'S can cause postpartum bleeding and breathing problems in infants.
Q. Is there any special monitoring associated with the Dulan 60mg Capsule 10 'S?
Blood pressure monitoring is necessary if you are a hypertensive patient. Dulan 60mg Capsule 10 'S causes an elevation in liver enzymes. So monitoring is also important in case you have any liver disease.
Q. Can I consume alcohol with Dulan 60mg Capsule 10 'S?
As Dulan 60mg Capsule 10 'S causes sedation and dizziness, it is better to avoid alcohol until you get stable. Alcohol consumption should be stopped especially in the initial phase of treatment.
Q. Are there any dietary recommendations associated with Dulan 60mg Capsule 10 'S?
There are not any specific recommendations about diet while taking Dulan 60mg Capsule 10 'S. You can take it along with any food until your doctor limits it.
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