Anplag 90mg Tablet 10 'S

Anplag 90mg Tablet 10 'S belongs to a class of drugs called “antiplatelet agents”, commonly referred to as blood thinners used for the prevention of heart attacks and strokes. It helps decrease the chances of having another heart attack or stroke in patients who have a history of chronic heart disease or heart surgery by easing out the blood flow and circulation through blood vessels. Conditions benefiting from Anplag 90mg Tablet 10 'S include venous thrombocytosis, rheumatic disease, post-coronary artery bypass grafting surgery, stents, or used in combination with other agents such as aspirin for mechanical heart valves and high-risk patients.

Anplag 90mg Tablet 10 'S is chemically composed of Ticagrelor, which works by acting on a particular receptor on platelets involved in clotting and blocking its effects thereby preventing platelets from sticking together into a clot form. This lowers the chance of heart attack or stroke. According to the clinical measures, Anplag 90mg Tablet 10 'S may be prescribed in combination therapy with aspirin or another anticoagulant.

 

How does Anplag 90mg Tablet 10 'S work?

Anplag 90mg Tablet 10 'S acts on the “P2Y12” receptor located on platelets and works by antagonizing its effects, decreasing the formation of blood clots by preventing platelets from sticking together into a clot form known as the “aggregation” phenomenon. Thereby, lowering the chances of heart attack or stroke. 

 

It can be used for the prevention of atherothrombotic episodes in patients suffering from:

• Myocardial infarction - heart attack (history of a previous attack),
• Acute ischemic - a blood clot that blocks the vessel in the brain 
• Established peripheral artery disease (narrowed arteries reducing blood flow to arms/legs)
• Primary prevention of coronary artery disease
• Device closure of an atrial septal defect (ASD) for at least six months
• Combination therapy with aspirin or warfarin for mechanical heart valves
• Unstable angina
• After percutaneous intervention with stents
• Rheumatic heart disease

Dosage

Adult Dose

Acute Coronary Syndrome such as a sudden heart attack: It is important to take blood thinners at least up to one year after a major episode of attack, stroke, or any other acute heart condition to avoid recurrence.

Loading dose: 180 mg orally, once a day

Maintenance dose: Up to 1 year 90 mg, twice a day, then 60 mg orally, twice a day (after one year of maintenance)

Coronary Artery Disease: When there is no previous history of an attack or stroke, the patient is considered to be at high risk such as patients with Diabetes.

60 mg orally, twice a day (morning and evening) in combination with aspirin 75-100 mg once daily

Transient ischemic attack (ischemic stroke): To decrease the chances of stroke in high-risk patients. 

Loading dose: 180 mg Anplag 90mg Tablet 10 'S orally in combination with 300-325 mg aspirin 

Maintenance dose of Anplag 90mg Tablet 10 'S: Up to 1 month 90 mg orally, twice a day

Maintenance dose of aspirin:  75-100 mg once daily

 

Special Dosage Instructions

Caution is advised in case of severe liver impairment and renal dose. Consult your physician regarding dose adjustment. Taking aspirin more than 100 mg alongside Anplag 90mg Tablet 10 'S can reduce the therapeutic effects of Anplag 90mg Tablet 10 'S, large doses of aspirin should be avoided when used concurrently.

Anplag 90mg Tablet 10 'S is not prescribed to children younger than 18 years of age due to safety concerns.                                                                          Caution is advised while using Anplag 90mg Tablet 10 'S in the elderly population. Strictly follow your doctor’s prescription.

 

Pregnancy use and lactation

Anplag 90mg Tablet 10 'S contains Ticagrelor in its formulation which is classified as pregnancy category C (A known risk and malformations observed in the fetus during studies conducted on animals and lack of data in pregnant women). Therefore, this drug should not be prescribed to expecting mothers due to unknown effects. Anplag 90mg Tablet 10 'S is secreted in human milk in small quantities but consult a doctor first regarding its safety in lactation. It should only be prescribed if considered necessary after consulting a doctor. 

 

How to use Anplag 90mg Tablet 10 'S?

Anplag 90mg Tablet 10 'S is available as tablets. Anplag 90mg Tablet 10 'S is usually prescribed to be taken twice a day around the same time every day, with or without food. Take Anplag 90mg Tablet 10 'S as prescribed by your doctor. Do not chew or crush the tablet. The dose may initially be started on high potency and then reduced as clinical improvement is noticed.

Like most medicines, Anplag 90mg Tablet 10 'S has some side effects which include:

• Prolonged /easy bleeding (you may have nosebleeds, heavier menses, or bleeding gums) 
• Diarrhea
• Indigestion or heartburn
• Stomachache
• Shortness of breath 
• Easy bruising 

Precautions

Please tell your doctor about any of the following conditions before using Anplag 90mg Tablet 10 'S:

• Anplag 90mg Tablet 10 'S must be used with caution if you have a history of drug-related allergies
• In case of impaired liver function, Anplag 90mg Tablet 10 'S must not be used since it is taken up and processed in the liver. It can cause increased bleeding.
• If you suffer from blood disorders, make sure to discuss them with your doctor first
• Avoid activities that are likely to cause injury or provoke bleeding while using Anplag 90mg Tablet 10 'S
• Anplag 90mg Tablet 10 'S can result in abnormal bleeding. Report to your doctor if you notice abnormal bleeding such as in stool, cough, vomit, nose, etc.
• Do not stop taking Anplag 90mg Tablet 10 'S without consulting a doctor
• In case you are scheduled for surgery (major or minor including dental treatment), after discussing with your doctor Anplag 90mg Tablet 10 'S should be stopped 5-7 days before surgery
• Alcohol intake should be restricted
• Do not take other blood thinners unless advised by your doctor
• Analgesics like aspirin, NSAIDs like ibuprofen, naproxen, etc. should be avoided with Anplag 90mg Tablet 10 'S, for it can evoke bleeding
• Anplag 90mg Tablet 10 'S is not considered safe for pregnant and lactating mothers. If it is advised during breastfeeding due to your condition, monitor your baby carefully for side effects
• Anplag 90mg Tablet 10 'S must be used with caution in patients with a history of blood uric acid 
• While undergoing tests, provide a list to your lab personnel

Contraindications

Please tell your doctor if you have a history of any of the following before using Anplag 90mg Tablet 10 'S:

• Allergy to Anplag 90mg Tablet 10 'S or similar drugs
• Recent traumatic injury, currently bleeding or at risk to bleed
• History of intracranial bleeding (bleeding in the brain) 
• Bleeding stomach ulceration/ perforation
• Breathing problems such as asthma, chronic lung disease like COPD
• Bradycardia 
• Blood disorders such as hemophilia 
• Hyperuricemia or conditions such as gout
• Pregnancy 
• Children younger than 18 years of age
• Severe liver dysfunction
• Scheduled for surgery major or minor including dental treatment (within a week)

Certain medications could interact with Anplag 90mg Tablet 10 'S some of which are enlisted below, hence, inform your doctor about the use of the CYP3A inhibitors or the following before taking Anplag 90mg Tablet 10 'S:

• Other P2Y12 antagonist anticoagulants
• Phenytoin
• Aspirin (more than 100 mg)
• Anti convulsant such as phenobarbital, Carbamazepine 
• Rifampicin 
• Digoxin 
• Cyclosporine
• Clarithromycin 
• Ketoconazole
• Quinidine 
• Calcium channel blockers like Diltiazem/verapamil
• Cholesterol-controlling drugs like simvastatin, lovastatin 
• Antivirals like HIV drugs atazanavir, ritonavir etc
• Morphine, oxy/hydrocodone, and other opioids
• NSAIDs like naproxen, ibuprofen
• SSRI antidepressants like citalopram

 

#1. How long does it take for Anplag 90mg Tablet 10 'S to start working?

Anplag 90mg Tablet 10 'S starts working within 1 hour of ingestion. 

#2. How long will I have to take Anplag 90mg Tablet 10 'S for?

The duration for using Anplag 90mg Tablet 10 'S depends on the severity of your condition. It is commonly prescribed for up to one year, or you may have to take it for a longer period as prescribed by your doctor. 

#3. Can I stop taking Anplag 90mg Tablet 10 'S?

Do not just stop taking the medicine, make sure to complete your treatment even if you feel better. Stopping it will put you at a higher risk of serious problems like heart attacks or strokes. 

#4. Can I drink alcohol with Anplag 90mg Tablet 10 'S?

Yes, but taking it in excess can damage your liver and stomach. Avoid consuming alcohol in large amounts when taking Anplag 90mg Tablet 10 'S to prevent the risk of stomach problems.

#5. Can I take Anplag 90mg Tablet 10 'S during pregnancy or breastfeeding?

If you are pregnant or are planning to have a baby, please consult your doctor before using Anplag 90mg Tablet 10 'S as it is contraindicated unless considered necessary. If you are breastfeeding, please consult your doctor before taking Anplag 90mg Tablet 10 'S as it may pose a risk to your baby.

#6. How does Anplag 90mg Tablet 10 'S compare with other antiplatelet medicines like clopidogrel?

Clopidogrel prevents blood clots and future heart attacks or stroke (if you have already had one) but Anplag 90mg Tablet 10 'S is not approved to prevent further strokes (if you have already had one). Anplag 90mg Tablet 10 'S is usually taken twice a day unlike clopidogrel which is taken once a day and Anplag 90mg Tablet 10 'S is known to cause more bleeding when compared to ticagrelor. 

#7. Is it safe to use Anplag 90mg Tablet 10 'S for a long time?

Anplag 90mg Tablet 10 'S is generally safe to take for a long time. It works best if you take it for many months or even years. At times it may result in a stomach ulcer, but for that, your doctor may prescribe a medicine to help prevent any ulcers from forming while taking Anplag 90mg Tablet 10 'S. 

#8. Will I have to stop taking Anplag 90mg Tablet 10 'S before surgery or dental treatment?

Do not stop taking Anplag 90mg Tablet 10 'S without consulting with your doctor or dentist. You will be informed if you need to stop taking it before any procedure. You might be advised to stop taking it for a short time before a procedure because of the risk of bleeding. 

#9. How should Anplag 90mg Tablet 10 'S be stored?

Keep the medicine at room temperature in a cool, dry place, away from direct sunlight. Make sure it is not consumed by pets, children, and other people. Dispose of unused medicine when it is expired or no longer needed. 

#10. Will it affect my menstrual cycle?

There is an increased tendency to bleed. Few women may experience heavier periods or vaginal bleeding. Report to your doctor if you notice this.

#11. Can I take painkillers with Anplag 90mg Tablet 10 'S?

NSAIDs like ibuprofen and naproxen which are likely to cause bleeding should be avoided. For pain relief, paracetamol (acetaminophen) can be taken while treatment.

#12. Is there any food product I need to avoid with Anplag 90mg Tablet 10 'S?

It is recommended to avoid taking grapefruit juice or grapefruit with Anplag 90mg Tablet 10 'S as it may render the drug to act less effectively.